The Winchesters take one more ride starting Sept. 24 as Supernatural returns for a sixth season. The conflict between Heaven vs. Hell is over (or is it?). The brothers are separated once again. There’s already more than a handful of questions out in the open. The major question now is, “What’s changed?”

The CW announced recently that the show won’t be returning to air Thursday nights. Following suit with Smallville, Supernatural moves to 9 p.m. Friday nights. Series creator Eric Kripke will be stepping down as show frontrunner and handing the reigns over to Sera Gamble. Kripke promises that he’s not done with the show with prospects of writing  and even directing an episode or two, but with the major storyline of Supernatural finished, Kripke can now pass the heavy lifting off to someone just as capable and committed to the story and the fans. This, by far, spells the biggest of the changes happening for the show.

A recent interview with Kripke also revealed assurances that’ll get everyone’s attention. Two-times born-again Angel Castiel will be back for season 6 as well as fan-favorite and extremely comical Crossroads Demon Crowley (played by Battlestar Galactica and Firefly alum Mark Sheppard). The writers also plan to shed light onto more of the Winchester’s past when Mitch Pileggi (The X-Files, Stargate: Atlantis) returns as granddad Samuel Campbell. The Campbells play a bigger part in the storyline since they were the actual origins of the Winchesters hunter past — going as far back as the Pilgrims and the Mayflower.

Origins for the Winchesters isn’t all that’s going to be explored during season 6. A lot of lore from the Supernatural universe is set to be uncovered. Vampires, werewolves, shape-shifters… How did they all come about in the first place? As the show’s final season hits this fall, questions will be answered while quite possibly a few more get asked.